Aberrantly expressed PLOD1 promotes cancer aggressiveness in bladder cancer: a potential prognostic marker and therapeutic target.
作者： Yasutaka Yamada , Mayuko Kato , Takayuki Arai , Hiroki Sanada , Akifumi Uchida
关键词:
摘要: Bladder cancer (BC) is the ninth most malignant tumor worldwide. Some BC patients will develop muscle-invasive (MIBC), which has a 5-year survival rate of approximately 60% due to metastasis. As such, there an urgent need for novel therapeutic and diagnostic targets MIBC. Analysis antitumor microRNA (miRNA)-mediated networks effective strategy exploring prognostic markers in cancers. Our previous miRNA analysis revealed that miR-140-5p acts as cells. Here, we investigated regulation molecular pathogenesis. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) was found be directly regulated by miR-140-5p, aberrant expression PLOD1 observed clinical specimens. High significantly associated with poor prognosis (disease-free survival: P = 0.0204; overall 0.000174). Multivariate showed independent factor (hazard ratio 1.51, 0.0099). Furthermore, downregulation siRNAs specific inhibitor decreased cell aggressiveness. Aberrant closely In summary, present study may potential marker target BC.
sci-hub.se 参考文章(46)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Yusuke Goto, Akira Kurozumi, Hideki Enokida, Tomohiko Ichikawa, Naohiko Seki, Functional significance of aberrantly expressed microRNAs in prostate cancer International Journal of Urology. ,vol. 22, pp. 242- 252 ,(2015) , 10.1111/IJU.12700
R Matsushita, N Seki, T Chiyomaru, S Inoguchi, T Ishihara, Y Goto, R Nishikawa, H Mataki, S Tatarano, T Itesako, M Nakagawa, H Enokida, Tumour-suppressive microRNA-144-5p directly targets CCNE1 / 2 as potential prognostic markers in bladder cancer British Journal of Cancer. ,vol. 113, pp. 282- 289 ,(2015) , 10.1038/BJC.2015.195
Yusuke Goto, Satoko Kojima, Rika Nishikawa, Akira Kurozumi, Mayuko Kato, Hideki Enokida, Ryosuke Matsushita, Kazuto Yamazaki, Yasuo Ishida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki, MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker. British Journal of Cancer. ,vol. 113, pp. 1055- 1065 ,(2015) , 10.1038/BJC.2015.300
S. M. Mah, C. Buske, R. K. Humphries, Florian Kuchenbauer, miRNA*: a passenger stranded in RNA-induced silencing complex? Critical Reviews in Eukaryotic Gene Expression. ,vol. 20, pp. 141- 148 ,(2010) , 10.1615/CRITREVEUKARGENEEXPR.V20.I2.40
I Fukumoto, T Kinoshita, T Hanazawa, N Kikkawa, T Chiyomaru, H Enokida, N Yamamoto, Y Goto, R Nishikawa, M Nakagawa, Y Okamoto, N Seki, Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature British Journal of Cancer. ,vol. 111, pp. 386- 394 ,(2014) , 10.1038/BJC.2014.293
I Fukumoto, T Hanazawa, T Kinoshita, N Kikkawa, K Koshizuka, Y Goto, R Nishikawa, T Chiyomaru, H Enokida, M Nakagawa, Y Okamoto, N Seki, MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. British Journal of Cancer. ,vol. 112, pp. 891- 900 ,(2015) , 10.1038/BJC.2015.19
Cecilia Giunta, Ann Randolph, Beat Steinmann, Mutation analysis of the PLOD1 gene: an efficient multistep approach to the molecular diagnosis of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA). Molecular Genetics and Metabolism. ,vol. 86, pp. 269- 276 ,(2005) , 10.1016/J.YMGME.2005.04.014
Benjamin Wolfson, Roles of microRNA-140 in stem cell-associated early stage breast cancer World Journal of Stem Cells. ,vol. 6, pp. 591- 597 ,(2014) , 10.4252/WJSC.V6.I5.591
Kazumori Kawakami, Hideki Enokida, Tokushi Tachiwada, Kenryu Nishiyama, Naohiko Seki, Masayuki Nakagawa, Increased SKP2 and CKS1 gene expression contributes to the progression of human urothelial carcinoma. The Journal of Urology. ,vol. 178, pp. 301- 307 ,(2007) , 10.1016/J.JURO.2007.03.002