Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome

摘要: We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization–defined polycythemia vera evaluated at time initial diagnosis. Seventy-four (14%) displayed mostly grade 1 fibrosis, only 2 cases showing higher-grade fibrosis. Presenting clinical laboratory characteristics, including JAK2V617F allele burden, between without were similar for most part, exception a higher palpable splenomegaly ( P < .01). Patients less prone to experience thrombosis during their course (1.1 vs 2.7 per 100 patient-years; = .03) more develop post-polycythemia myelofibrosis (2.2 0.8 There was no significant difference groups terms overall or leukemia-free survival. The present study clarifies incidence, degree, obtained diagnosis vera.