Macronutrient metabolism of adipose tissue at rest and during exercise: a methodological viewpoint

摘要: The metabolism of white adipose tissue is regulated by many factors, including hormones and substrates delivered in the blood, activity autonomic nervous system rate flow blood through tissue. An integrated view can only be gained, therefore, from studies vivo. Of various techniques available for studying vivo, measurement arterio-venous differences offers some unique possibilities. In human subjects this technique has been performed mostly catheterization venous drainage subcutaneous abdominal depot. Studies using indicate that an active pattern metabolism, responding rapidly to meal ingestion suppressing release non-esterified fatty acids, or exercise with increase fat mobilization. Adipose may also change these situations; instance, it increases markedly after a meal, potentially increasing delivery triacylglycerol enzyme lipoprotein lipase (EC 3.1.1.34) hydrolysis. During exercise, there evidence does not sufficiently allow all acids released into systemic circulation. depots have their own characteristic metabolic properties, although are difficult study difference technique. A combination tracer infusion selective allows measurements leg, splanchnic non-splanchnic upper-body mobilization clearance. Development such open up new possibilities future obtaining picture function its depot-specific variations.