Column ion exchange chromatographic production of human immune serum globulin for intravenous use
作者： A.D. Friesen , J.M. Bowman , W.C.H. Bees
DOI: 10.1111/J.1423-0410.1985.TB00173.X
关键词:
摘要: . Column ion exchange chromatographic processes were developed for the production of immune serum globulin (ISG) intravenous use. Sequential chromatography on two cross-linked agarose gel anion exchangers yielded same immunoelectrophoretic pure ISG as a single column DEAE-Sephadex procedure with advantage repeated ‘in column’ cycling. low content aggregated IgG and anticomplementary activity was prepared from plasma 53–69% efficiency. The by these characterized respect to IgA, prekallikrein activator (PKA), plasminogen, fragmentation, heavy chain subclass distribution.
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