WinRho: Rh immune globulin prepared by ion exchange for intravenous use

摘要: An Rh immune globulin [Rh IgG] for intravenous use, WinRho, has been prepared by the Winnipeg Institute a modification of ion-exchange column method Hoppe and colleagues. When administered to Rh-negative male nonpregnant female volunteers WinRho was found be nonpyrogenic, nontoxic, safe protective against alloimmunization. In clinical trial with 240 microgram given at about 28 weeks9 gestation 120 after delivery women risk immunization effective in preventing immunization. Of 870 carrying Rh-positive fetuses who were treated during pregnancy not tested several months 14 would have shown evidence time if had ineffective; none showed such evidence. 1122 retested 4 6 83 that only 1 The efficiency yield anti-D modified production, fct it can intravenously (a route causes patient less discomfort immediately results high levels) lower levels contaminating IgA IgM make preparation choice