A retrospective study of the impact of lifestyle on age at onset of Huntington disease.

摘要: In transgenic mouse models of Huntington disease (HD) environmental enrichment significantly delays onset. A questionnaire-based survey 154 adults with diagnosed HD (mean 4.2 years postdiagnosis) and a known IT15 CAG repeat length, explored whether premorbid lifestyle may relate to age-at-onset (AO). Participants were drawn from outpatient clinics in Australia New Zealand. Premorbid physical, intellectual, passive activity levels used generate scores the categories leisure, nonleisure (education, occupation domestic duties) total lifestyle. AO was associated increased length as expected (r = -0.72, P < 0.001), but also that included higher -0.38, 0.001). Multiple linear regression modeling showed passivity be variable independent predicting (R(2) 0.54, b -0.22, 0.005). Comparison mean across tertiles onset 4.6 (95% CI 1.3-7.9) later least compared most tertile. shown predict 0.12, 1.08, 0.0005). Neither intellectual nor physical significant relationships or this cohort. Our study leads two conclusions: preclinical expression HD, it actually contributes earlier symptoms. Overcoming tendency substantially delay HD. (c) 2010 Movement Disorder Society.