Aerosolization properties, surface composition and physical state of spray-dried protein powders.
作者： Cynthia Bosquillon , Paul G. Rouxhet , François Ahimou , Denis Simon , Christine Culot
DOI: 10.1016/J.JCONREL.2004.07.022
关键词:
摘要: Powder aerosols made of albumin, dipalmitoylphosphatidylcholine (DPPC) and a protein stabilizer (lactose, trehalose or mannitol) were prepared by spray-drying analyzed for aerodynamic behavior, surface composition physical state. The powders exited Spinhaler inhaler as particle aggregates, the size which depending on composition, parameters airflow rate. However, due to low bulk powder tap density (<0.15 g/cm3), large fraction aggregates remained respirable (<5 microm). Fine fractions ranged between 21% 41% in an Andersen cascade impactor operated at 28.3 l/min, with mannitol lactose providing most cohesive free-flowing powders, respectively. Particle analysis X-ray photoelectron spectroscopy (XPS) revealed enrichment DPPC relative albumin under certain conditions. self-organized gel phase no sugar crystals detected diffraction. Water sorption isotherms showed that protected from moisture-induced crystallization. In conclusion, proper combination allowed obtain dry elevated fine (FPFs) environment favorable stability.
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