Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates.

摘要: PURPOSE: The action spectrum of ultraviolet radiation mainly responsible for melanoma induction is unknown, but evidence suggests it could be A (UVA), which has a different geographic distribution than B (UVB). This study assessed whether mortality rates are more closely related to the global UVA or UVB. METHODS: and UVB age-adjusted were obtained all 45 countries reporting cancer data World Health Organization. Stratospheric ozone from NASA satellites. Average population skin pigmentation was reflectometry measurements. RESULTS: Paradoxically, decreased with increasing in men (r = −0.48, p < 0.001), women −0.57, both sexes. By contrast, positively associated UVA/UVB ratio + 0.49, 0.001) 0.55, 0.001). After multiple adjustment that included controlling pigmentation, only (p 0.02) suggestive non-significant trend present 0.12). CONCLUSIONS: after average pigmentation. results require confirmation observational studies.