Cyclic flow alterations and neointimal proliferation following experimental coronary stenosis and endothelial injury

摘要: We evaluated the hypothesis that recurrent platelet aggregation as evidenced by frequency and severity of cyclic coronary blood flow variations is an important pathophysiologic factor in development neointimal proliferation. In 24 chronically instrumented dogs, variable degrees artery proliferation were observed 3 weeks after mechanical injury arterial endothelium placement external constrictor. The at 21 days was closely related to during initial 7 instrumentation animals. Pharmacological therapy with a dual thromboxane A2 synthetase inhibitor receptor antagonist serotonin S2 frequently successful abolishing appeared attenuate