Dose- and duration-dependent alterations by tellurium on lipid levels: differential effects in cerebrum, cerebellum, and brain stem of mice.

摘要: The effect of various doses sodium tellurite (1/50 LD50=0.4 mg/kg, 1/25 LD50=0.8 and 1/10 LD50=2.0 mg/kg body weight orally) on the lipid levels (cholesterol, triglycerides, phospholipids, esterified fatty acids, gangliosides, total lipids) in cerebrum, cerebellum, brainstem male albino mice was studied after 7 15 d treatment. Sodium (2.0 weight) for has an apparent depletion cholesterol, lipids. cholesterol content decreased significantly treatment with a 2.0-mg/kg dose compared to control. On other hand, 0.4, 0.8, 2.0 resulted significant dose-dependent increment level brainstem. triglycerides orally All tellurium (0.4, mg/kg) both have depleted phospholipids varying degrees significance However, acids but increased 0.4-mg/kg cerebrum cerebellu. gangliosides elevated cerebellum receiving d. 0.4 0.8 lipids dependently These results suggest that affects differentially parts brain.