Influence of Obesity and Related Metabolic Alterations on Colorectal Cancer Risk

摘要: Obesity and related metabolic alterations have been implicated to play a role in colorectal cancer risk. The syndrome, as assessed according current international definitions by the key components, abdominal obesity, dyslipidemia, elevated blood pressure, abnormal glucose metabolism, is associated with cancer. Recent studies suggest that obesity metabolism may primarily account for this association. Visceral adipose tissue physiologically more active than subcutaneous generates hormones cytokines inflammatory, metabolic, direct carcinogenic potential, which directly or indirectly increase Current evidence suggests acts risk factor several mechanisms, including chronic low-grade inflammation, hyperinsulinemia, well insulin-like growth adipokine concentrations. Metabolic biomarkers reflecting these processes not only provide clues etiological understanding of carcinogenesis but also might be an alternative way define “obesity phenotype” relevant development.