Deficits in auditory predictive coding in individuals with the psychosis risk syndrome: Prediction of conversion to psychosis.

摘要: The mismatch negativity (MMN) event-related potential (ERP) component is increasingly viewed as a prediction error signal elicited when deviant sound violates the that frequent "standard" will repeat. Support for this predictive coding framework emerged with identification of repetition positivity (RP), standard stimulus ERP increases and thought to reflect strengthening standard's memory trace associated code. Using electroencephalographic recordings, we examined RP by repeating tones presented during traditional "constant standard" MMN paradigm in individuals psychosis risk syndrome (PRS; n = 579) healthy controls (HC; 241). Clinical follow-up assessments identified PRS participants who converted psychotic disorder (n 77) nonconverters were followed entire 24-month clinical period either remained symptomatic 144) or remitted from 94). In HC, linearly increased early- late-appearing standards within local trains (p < .0001), consistent auditory code/memory strengthening. Relative showed reduced across .0056). converters relatively small deficit early appearing relative HC .0.0107) more prominent .0006) both PRS-remitted groups. Moreover, greater deficits predicted shorter time conversion subsample unmedicated .02). Thus, coding/memory precede onset predict future individuals. (PsycInfo Database Record (c) 2020 APA, all rights reserved).