Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair

摘要: The gastrointestinal mucosa, structurally formed by the epithelium and lamina propria, serves as a selective barrier that separates luminal contents from underlying tissues. Gastrointestinal mucosal wound repair is orchestrated series of spatial temporal events involve epithelium, recruited immune cells, resident stromal microbiota present in bed. Upon injury, mediated collective migration, proliferation, subsequent differentiation epithelial cells. Epithelial intimately regulated number wound-associated cells include addition to mediators released microbiota. highly interaction these cell types perturbed chronic inflammatory diseases are associated with impaired healing. An improved understanding prorepair mechanisms mucosa will aid development novel therapeutics promote healing reestablish critical function.