Estimated Plasma Bupivacaine Concentration After Single Dose and Eight-Hour Continuous Intra-Articular Infusion of Bupivacaine in Normal Dogs

摘要: OBJECTIVE To estimate maximum plasma concentration (C(max)) and time to (t(max)) bupivacaine after intra-articular administration of for single injection (SI) followed by continuous infusion (CI) in normal dogs. STUDY DESIGN Cross-over design with a 2-week washout period. ANIMALS Healthy Coon Hound dogs (n=8). METHODS Using gas chromatography/mass spectrometry, canine was measured before SI (1.5 mg/kg) CI mg/kg 0.3 mg/kg/h). Software used establish concentration-time curves C(max), T(max) other pharmacokinetic variables comparison CI. RESULTS Bupivacaine best fit 3 exponential model. For SI, mean (C(max), 1.33+/-0.954 microg/mL) occurred at 11.37+/-4.546 minutes. CI, C(max) (1.13+/-0.509 10.37+/-4.109 The area under the curve smaller (143.59+/-118.390 microg/mL x min) than (626.502+/-423.653 min, P=.02) half-life shorter (61.33+/-77.706 minutes) (245.363+/-104.415 minutes, P=.01). highest any dog 3.2 2.3 CONCLUSION Intra-articular results delayed absorption from stifle into systemic circulation below that considered toxic no drug accumulation. CLINICAL RELEVANCE can be administered small risk reaching concentrations dogs, though may approached. Caution should exercised multimodal because rise higher injection.