Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics

摘要: There is widespread evidence that schizophrenic symptomatology best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samples predominantly treated typical neuroleptics, which frequently induce parkinsonian symptoms are hard disentangle from primary may inflated correlations neurocognition. A newly developed psychopathological instrument called Positive Negative Disorganized Symptoms Scale (PANADSS) was evaluated in 60 patients. Forty-seven participants atypical neuroleptics performed tasks.A three-factor solution of emerged. associated diminished creative verbal fluency digit span backward, whereas disorganization significantly correlated impaired Stroop, WCST Trail-Making Test B performance.Data suggest tasks demand executive functioning. Previous findings reporting between neurocognition confounded adverse consequences neuroleptics.