What are we learning from the cancer genome
作者： Eric A. Collisson , Raymond J. Cho , Joe W. Gray
DOI: 10.1038/NRCLINONC.2012.159
关键词:
摘要: Massively parallel approaches to nucleic acid sequencing have matured from proof-of-concept commercial products during the past 5 years. These technologies are now widely accessible, increasingly affordable, and already exerted a transformative influence on study of human cancer. Here, we review new features cancer genomes that being revealed by large-scale applications these technologies. We focus those insights most likely affect future clinical practice. Foremost among lessons, summarize formidable genetic heterogeneity within given types is appreciable with higher resolution profiling larger sample sets. discuss inherent challenges defining driving genomic events in genome amidst thousands other somatic events. Finally, explore organizational, regulatory societal impeding precision medicine based assuming its place as standard-of-care.
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