Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population.

摘要: Summary Background Genes linked to the major histocompatibility complex (MHC), have been implicated in atopic asthma. Asthma is highly prevalent Venezuelan population (estimated at 20%) and genetic markers are needed identify populations risk plan intervention strategies. Objective To study influence of MHC class I II genes susceptibility Methods MHC-class HLA-A, -C, -B HLA-DR, -DQ, -DP gene haplotype frequencies were determined 135 mestizos, 71 belong 20 asthmatic families 64 unrelated controls. The index cases asthmatics with positive skin-prick tests specific serum immunoglobulin E (IgE) for Dermatophagoides pteronyssinus (Der p) farinae f). ascertain associated atopy and/or asthma, two control groups studied, 41 non-atopic subjects negative test, undetectable levels IgE 23 non-asthmatic detectable Der p f. A linkage analysis was performed those or more siblings (with without asthma). Results showed that HLA-Cw7 absent patients whereas frequency this allele 14.3% controls (P o 0.017, PCo 0.19) 20.8% = 0.0066, 0.07). MHCclass a significant increase HLA-DRB1*11 compared (allele 25.6 vs 4.4% P 0.0017, 0.02). There no differences among (25.6 17.4%). In contrast, HLA-DRB1*1101˛ haplotypes significantly higher (19.6% 2.2% 2.3%, PC< 0.05). HLA-DRB1*1101, DQA1*0501, DQB1*0301 found increased (15.4 1.1%, 0.01). both controls; however, it (median, 58.7 2.7 kU/L, P< 0.001) f 46.9