Serum eosinophil cationic protein as a marker of eosinophilic inflammation in asthma.

摘要: Background The serum level of eosinophil cationic protein (ECP) has been used as a clinical marker in asthma, on the assumption that it reflects ongoing eosinophilic inflammation airways. However, only few studies have investigated this issue, using bronchial secretions but not tissue specimens. Objective To evaluate cross-sectionally correlation between ECP or blood count, and degree eosinophilia bronchoalveolar lavage fluid (BALF) biopsy tissue, disease activity, asthmatic patients. Methods Thirty-three adults with symptomatic asthma six healthy controls were studied. levels BALF, percentage eosinophils number pulmonary function, methacholine responsiveness these subjects clarified. An severity score inhaled β 2 -agonist requirement (puffs/day) also assessed for Results patients, compared controls, had more obstructive (as tested by %FEV 1 , FEV /FVC, FEF 25-75% ) responsive airways, showed significant increase blood, levels. BALF below detection limit most both groups examined. In demonstrated correlations whereas count correlated BALF. Serum all indices activity examined; responsiveness, usage, responsiveness. Conclusion data suggest intensity airway inflammation, well may be useful an inflammatory asthma.