Ulipristal acetate: a review of its use in emergency contraception.

摘要: Ulipristal acetate (ellaOne(R); ella(R)) is the first of a new class selective progesterone receptor modulators and indicated for emergency contraception within 120 hours after unprotected sexual intercourse or contraceptive failure. The principal effect ulipristal to inhibit delay ovulation. This may result from drugs ability onset luteinizing hormone (LH) surge postpone LH peak if has started possibly by direct inhibitory on follicular rupture when administered in phase (including just before ovulation). In clinical trials single oral dose 30 mg was effective preventing pregnancies women requesting provided sustained efficacy throughout 120-hour postcoital period which it indicated. When compared with levonorgestrel well designed noninferiority no less 72 but more later (within 72-120 hours). Results meta-analysis suggest that be than day 1 entire 5-day following intercourse. generally tolerated similar tolerability profile levonorgestrel. general menses delayed 2-3 days treatment. Although expensive represent cost-effective alternative Thus provides taken thereby offering an extended treatment window should hours. (c) 2011 Adis Data Information BV. All rights reserved.