The Role of Drosophila Heparan Sulfate 6-O-Endosulfatase in Sulfation Compensation*
作者： Katsufumi Dejima , Adam Kleinschmit , Masahiko Takemura , Pui Yee Choi , Akiko Kinoshita-Toyoda
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摘要: The biosynthesis of heparan sulfate proteoglycans is tightly regulated by multiple feedback mechanisms, which support robust developmental systems. One the regulatory network systems controlling (HS) sulfation compensation. A previous study using Drosophila HS 2-O- and 6-O-sulfotransferase (Hs2st Hs6st) mutants showed that loss at one position compensated increased other positions, supporting normal FGF signaling. Here, we show compensation rescues both Decapentaplegic Wingless signaling, suggesting a universal role this system in pathways Drosophila. Furthermore, identified Sulf1, extracellular 6-O-endosulfatase, as novel component Simultaneous Hs2st Sulf1 led to 6-O-oversulfation, leading patterning defects, overgrowth, lethality. These phenotypes are caused least partly abnormal up-regulation Hedgehog Thus, depends on coordinated activities Hs2st, Hs6st, Sulf1.
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