The role of T-regulatory cells in pregnancy and cancer
作者： Jacek R Wilczynski , Jaroslaw Kalinka , Michal Radwan
DOI: 10.2741/2841
关键词:
摘要: The acceptance of paternally-derived alloantigens during pregnancy and escape from host immunosurveillance by cancer are based on similar immunological mechanisms. Among them both natural peripherally-induced T CD4+ CD25+ Foxp3+ Tr1 regulatory cells (Tregs) play important role. Interactions Tregs with other immunocytes including dendritic cells, mechanisms recruitment their suppressive properties in have been presented this paper. Despite the fact that Treg regulation still progress, there is a hope for use Tregs-related immunotherapy clinical practice, first attempts such management already described. However, more information about function needed to provide safe treatment devoid potential side-effects. Resolving secrets will probably offer new options help improve failure.
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