Inflammatory biomarker, neopterin, predominantly enhances myelopoiesis, which suppresses erythropoiesis via activated stromal cells.
作者： Isao Tsuboi , Tomonori Harada , Yoko Hirabayashi , Jun Kanno , Tohru Inoue
DOI: 10.1016/J.IMBIO.2009.05.004
关键词:
摘要: Neopterin is produced by monocytes and a useful biomarker for inflammation. We found previously that neopterin enhanced myelopoiesis but suppressed B-lymphopoiesis triggered the positive negative regulations of cytokines stromal cells in mice. The effects on erythropoiesis during enhancement were determined present study using C57BL/6J intravenous injection into mice resulted prolonged decrease number femoral erythroid progenitor (BFU-Es CFU-Es), whereas myeloid (CFU-GMs) was increased. Interestingly, oscillatory changes reciprocal to those cells. expression Cdc42, regulator balance between myelopoiesis, down-regulated, implying suppression due myelopoietic predominance. Furthermore, SDF-1 cells, erythropoiesis, up-regulated. These results suggest facilitates bone marrow suppressing thereby contributing potential up-regulation inflammatory process.
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