The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans
作者： Jashvant D. Unadkat , Brian J. Kirby , Christopher J. Endres , Joseph K. Zolnerciks
DOI: 10.1007/978-1-4419-0840-7_21
关键词:
摘要: Drug transport proteins have been recognized as significant contributors to drug absorption, distribution, elimination, toxicity, and efficacy. This chapter will discuss the key concepts of transporter-based drug–drug interactions (DDIs), provide a concise review DDIs involving major transporters, describe methodologies used quantitatively predict magnitude in humans.
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