Toll-Like Receptor Agonists Are Potent Inhibitors of Human Immunodeficiency Virus-Type 1 Replication in Peripheral Blood Mononuclear Cells
作者： Maarten Buitendijk , Susan K. Eszterhas , Alexandra L. Howell
关键词:
摘要: Abstract Innate immune responses to microbial pathogens are initiated following the binding of ligand specific pattern recognition receptors. Each receptor, which includes members Toll-like receptor (TLR) family, is for a particular type pathogen associated molecular ensuring that organism can respond rapidly wide range including bacteria, viruses, and fungi. We studied extent agonists endosomal TLR could induce anti-HIV-1 activity in peripheral blood mononuclear cells (PBMCs). When TLR3, TLR7, TLR8 TLR9 were added prior infection with HIV-1, they significantly reduced cells. Interestingly, highly effective at blocking HIV replication even when as late 48 h or 72 h, respectively, after HIV-1 infection, indicating anti-viral effect was durable long lasting. Analysis induction genes after...
sci-hub.se 参考文章(59)
Ozlem Equils, Marco L. Schito, Hiase Karahashi, Zeynep Madak, Ayse Yarali, Kathrin S. Michelsen, Alan Sher, Moshe Arditi, Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. Journal of Immunology. ,vol. 170, pp. 5159- 5164 ,(2003) , 10.4049/JIMMUNOL.170.10.5159
Iris Caramalho, Thiago Lopes-Carvalho, Dominique Ostler, Santiago Zelenay, Matthias Haury, Jocelyne Demengeot, Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide Journal of Experimental Medicine. ,vol. 197, pp. 403- 411 ,(2003) , 10.1084/JEM.20021633
Nan Yan, Ashton D Regalado-Magdos, Bart Stiggelbout, Min Ae Lee-Kirsch, Judy Lieberman, The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 Nature Immunology. ,vol. 11, pp. 1005- 1013 ,(2010) , 10.1038/NI.1941
E. Chiffoleau, J.-M. Heslan, M. Heslan, C. Louvet, T. Condamine, M.-C. Cuturi, TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4+ CD25+ T cell. International Immunology. ,vol. 19, pp. 193- 201 ,(2006) , 10.1093/INTIMM/DXL136
Filiz Civril, Tobias Deimling, Carina C. de Oliveira Mann, Andrea Ablasser, Manuela Moldt, Gregor Witte, Veit Hornung, Karl-Peter Hopfner, Structural mechanism of cytosolic DNA sensing by cGAS Nature. ,vol. 498, pp. 332- 337 ,(2013) , 10.1038/NATURE12305
Leonie Unterholzner, Sinead E Keating, Marcin Baran, Kristy A Horan, Søren B Jensen, Shruti Sharma, Cherilyn M Sirois, Tengchuan Jin, Eicke Latz, T Sam Xiao, Katherine A Fitzgerald, Søren R Paludan, Andrew G Bowie, IFI16 is an innate immune sensor for intracellular DNA. Nature Immunology. ,vol. 11, pp. 997- 1004 ,(2010) , 10.1038/NI.1932
Hua Nian, Wen-Qing Geng, Hua-Lu Cui, Ming-jia Bao, Zi-ning Zhang, Min Zhang, Ying Pan, Qing-Hai Hu, Hong Shang, R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes BMC Infectious Diseases. ,vol. 12, pp. 5- 5 ,(2012) , 10.1186/1471-2334-12-5
Victoria Tüngler, Wolfgang Staroske, Barbara Kind, Manuela Dobrick, Stefanie Kretschmer, Franziska Schmidt, Claudia Krug, Mike Lorenz, Osvaldo Chara, Petra Schwille, Min Ae Lee-Kirsch, Single-stranded nucleic acids promote SAMHD1 complex formation Journal of Molecular Medicine. ,vol. 91, pp. 759- 770 ,(2013) , 10.1007/S00109-013-0995-3
Tsuneyasu Kaisho, Shizuo Akira, Toll-like receptors as adjuvant receptors Biochimica et Biophysica Acta. ,vol. 1589, pp. 1- 13 ,(2002) , 10.1016/S0167-4889(01)00182-3
R. Toroney, C. M. Hull, J. E. Sokoloski, P. C. Bevilacqua, Mechanistic characterization of the 5'-triphosphate-dependent activation of PKR: lack of 5'-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD. RNA. ,vol. 18, pp. 1862- 1874 ,(2012) , 10.1261/RNA.034520.112