Cytoplasmic retention and nuclear import of 5S ribosomal RNA containing RNPs.
作者： F. Rudt , T. Pieler
DOI: 10.1002/J.1460-2075.1996.TB00480.X
关键词:
摘要: Nuclear export of newly transcribed 5S ribosomal RNA in Xenopus oocytes occurs the context either a complex with protein L5 (5S RNP) or transcription factor IIIA (7S RNP). Here we examine nuclear import RNA, and TFIIIA. The RNP shuttles between nucleus cytoplasm only variants which can bind to gain access nucleus. 7S is retained cytoplasm. Only TFIIIA not bound imported into As novel mechanism for cytoplasmic retention, propose that binding masks localization sequence In contrast L5, sensitive towards (NLS) competitor p(lys)-BSA, suggesting these two proteins make use different pathways.
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