Patient Preferences in the Treatment of Neovascular Age-Related Macular Degeneration: A Discrete Choice Experiment.

摘要: Purpose The objective of our study was to investigate preferences patients with neovascular age-related macular degeneration (nAMD) for different anti-vascular endothelial growth factor (VEGF) treatment schemes. Design We used a discrete choice experiment (DCE) design as part telephone interview. Participants Patients nAMD aged at least 50 years were included in the study. Methods Telephone interviews done between November 2012 and October 2013. Main Outcome Measures In DCE survey, we measured patient toward specific levels attributes that describe options everyday intravitreal injection setting: (1) scheme; (2) change visual acuity (VA); (3) time needs each visit eye specialist. Results A total 284 mean age 77.4±7.1 (women: 59.9%) completed interviews. Of them, 22.9% had poor VA inclusion, 54.9% moderate VA, 14.1% good VA; not available 8.1% patients. Generally, preferred attribute "improvement VA" "short per specialist visit." results "treatment scheme" inconclusive because none (injections every 4 weeks, 8 pro re nata) associated statistically significant utility differences. This also mirrors relative importance decisions: "Change influenced decision making option 73.6% cases; "waiting, treatment, travel time" 21.0% 5.4% cases. To obtain improved instead worsening stated be willing accept very long needed physician 21.2 hours (8.5 rather than stable 12.7 VA). Conclusions prevent deterioration seem high burden regular injections short intervals periods waiting, traveling their consultations.