The interrelationship of sex steroid levels, body composition and bone characteristics in men

摘要: With this work, we showed that the relation between sex steroid levels, body composition and bone characteristics in men is complex bidirectional, influenced by environmental genetic factors. In elderly men, changes weight polymorphisms of genes involved action contribute to age-related decline androgen which was found continue up high age, especially bioavailable fractions. healthy at peak mass estradiol main contributing strength through associations with volumetric mineral density cortical geometry. In addition, provided evidence for a modulating effect estrogens on mechanical loading size, apart from direct effects these traits bone. same population, lean an important determinant whereas fat might have adverse size men. Further, interrelation composition, levels also evident observations cohorts idiopathic osteoporosis as well male-to-female transsexual persons. former group, observed decreased both trabecular sites, smaller thickness distinct anthropometric measures together lower compared controls. Moreover, similar phenotype their adult sons, indicating possible estrogen-related perturbances acquisition process during growth. group persons, altered deficits again illustrating importance steroids physical activity determining characteristics. From data, it appears are crucial determination men. Conversely, (changes in) will metabolism These findings respect rise obesity prevalence increasing exposure hormone-disrupting chemicals today’s society.