The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men

摘要: Aims/hypothesis. The relationship of androgens to the metabolic syndrome has not been resolved. polymorphic number CAG repeats within androgen receptor gene is inversely associated with transcriptional activity target genes.This polymorphism might thus influence testosterone effects on body fat content and serum concentrations leptin insulin. direct indirect role should become clearer if this genetically determined effector taken into account. Methods. hypothesis was investigated in a crosssectional study involving 106 healthy 20–50 year old males. Results. Multiple regression models showed positive independent correlation repeat content, insulin (partial r=0.39, 0.36 0.28, p<0.001, p<0.001 p=0.006, respectively). Factor analysis yielded five-dimensional model: two dimensions were influenced by polymorphism, namely “body composition” which consisted leptin, mass, insulin, (positive loadings) physical (negative loading), “lipid profile” comprised low density lipoprotein cholesterol, cigarette smoking, triglycerides as well high cholesterol loadings). Conclusions/interpretation. A independently protective parameters (low mass plasma insulin) adverse concentrations). This suggests that pivotal modulating cardiovascular risk factors complex nature implies its clinical impact, similar androgens, dependent exogenous cofactors. [Diabetologia (2003) 46:31–39]