Reactive hyperemia following coronary balloon angioplasty, but not dipyridamole-induced hyperemia, predicts resolution of exercise-induced ST-segment depression.

摘要: OBJECTIVES To characterize delayed restoration of coronary blood flow following successful percutaneous transluminal angioplasty (PTCA). BACKGROUND Delayed PTCA is common and likely the result multiple factors. Temporary myocardial ischemia dipyridamole administration both in increased flow, but by different mechanisms. The relationship between these phenomena exercise-induced ST-segment depression after was investigated to determine if any correlation existed. METHODS Forty consecutive patients with single-vessel artery disease underwent treadmill exercise testing before PTCA. percentage change 90 s balloon inflation assessed. After a new steady state had been reached, infused changes were again determined. presence during RESULTS Peak induced reactive hyperemia significantly greater than that (48.5+/-38.8 compared 15.1+/-13.2 ml/min, P<0.0001). Dipyridamole also resulted significant increases (15.1+/-13.2 ml/min 31.0+/-24.9 less (0.10+/-0.07 mV 0.19+/-0.08 mV, P<0.001). Further, hyperemia, not dipyridamole-induced correlated attenuation (r=0.62, CONCLUSIONS Reactive temporary occlusion recreates local conditions associated resolution this phenomenon appears be distinct from dipyridamole.