Coronary flow reserve varies depending upon the location within the artery it is assessed and the TIMI myocardial perfusion grade: a PROTECT TIMI-30 analysis

摘要: Coronary flow reserve (CFR) is a measure of the capacity epicardial coronary artery and microvasculature to achieve maximal blood in response hyperemic stimulation. It not known whether CFR varies along length artery. Likewise, interaction between thrombolysis myocardial infarction (TIMI) perfusion grade (TMPG) unknown. was measured using number cineframes required for contrast traverse same before following administration intracoronary adenosine. Following percutaneous intervention (PCI), assessed both proximal distal lesion 192 consecutive patients with non-ST-segment elevation acute syndrome (NSTEACS) from PROTECT TIMI-30 trial. TMPG also assessed. The difference 0/1 (n = 76) 0.11 (95% CI 0.01–0.20, P 0.026), while among those 2/3 114) it −0.02 −0.09–0.06, 0.65). segments significant (P 0.044). PCI impaired (0/1) setting NSTEACS, significantly segment arteries associated higher (greater) CFR.