Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
作者： C. Cimen Bozkus , B. D. Elzey , S. A. Crist , L. G. Ellies , T. L. Ratliff
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摘要: … Therefore, we hypothesized that restricting MDSC uptake of l-Arg is a critical control point to modulate their suppressor activity. Using murine models of prostate-specific inflammation …
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Bing Zhu, Yoshio Bando, Sheng Xiao, Kaiyong Yang, Ana C Anderson, Vijay K Kuchroo, Samia J Khoury, None, CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis Journal of Immunology. ,vol. 179, pp. 5228- 5237 ,(2007) , 10.4049/JIMMUNOL.179.8.5228
Patrick L. Raber, Paul Thevenot, Rosa Sierra, Dorota Wyczechowska, Daniel Halle, Maria E. Ramirez, Augusto C. Ochoa, Matthew Fletcher, Cruz Velasco, Anna Wilk, Krzysztof Reiss, Paulo C. Rodriguez, Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways. International Journal of Cancer. ,vol. 134, pp. 2853- 2864 ,(2014) , 10.1002/IJC.28622
Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, Dmitry I. Gabrilovich, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. Journal of Immunology. ,vol. 172, pp. 989- 999 ,(2004) , 10.4049/JIMMUNOL.172.2.989
C L MacLeod, K Finley, D Kakuda, C A Kozak, M F Wilkinson, Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Molecular and Cellular Biology. ,vol. 10, pp. 3663- 3674 ,(1990) , 10.1128/MCB.10.7.3663
R. DEVÉS, C. A. R. BOYD, Transporters for cationic amino acids in animal cells: discovery, structure, and function Physiological Reviews. ,vol. 78, pp. 487- 545 ,(1998) , 10.1152/PHYSREV.1998.78.2.487
Brian K. Helmich, Richard W. Dutton, The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors The Journal of Immunology. ,vol. 166, pp. 6500- 6508 ,(2001) , 10.4049/JIMMUNOL.166.11.6500
G. Gallina, L. Dolcetti, P. Serafini, C. D. Santo, I. Marigo, M. P. Colombo, G. Basso, F. Brombacher, I. Borrello, P. Zanovello, S. Bicciato, V. Bronte, Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells Journal of Clinical Investigation. ,vol. 116, pp. 2777- 2790 ,(2006) , 10.1172/JCI28828
Vincenzo Bronte, Paola Zanovello, Regulation of immune responses by L-arginine metabolism. Nature Reviews Immunology. ,vol. 5, pp. 641- 654 ,(2005) , 10.1038/NRI1668
Joseph E. Qualls, Chitra Subramanian, Wasiulla Rafi, Amber M. Smith, Liza Balouzian, Ashley A. DeFreitas, Kari Ann Shirey, Benjamin Reutterer, Elisabeth Kernbauer, Silvia Stockinger, Thomas Decker, Isao Miyairi, Stefanie N. Vogel, Padmini Salgame, Charles O. Rock, Peter J. Murray, Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1 Cell Host & Microbe. ,vol. 12, pp. 313- 323 ,(2012) , 10.1016/J.CHOM.2012.07.012
Robert W. Thompson, John T. Pesce, Thirumalai Ramalingam, Mark S. Wilson, Sandy White, Allen W. Cheever, Stacy M. Ricklefs, Stephen F. Porcella, Lili Li, Lesley G. Ellies, Thomas A. Wynn, Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLOS Pathogens. ,vol. 4, ,(2008) , 10.1371/JOURNAL.PPAT.1000023