The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors

摘要: We had previously examined the factors that regulate response of OVA-specific TCR-transgenic CD8 T cells to B16 OVA melanoma, growing as lung metastases. examine here whether same parameters operate for EG7, intradermally. Tc1 or Tc2 effector from OT-1 mice were injected either mixed with tumor i.v. at day 0 7. one-fifth one-tenth effective when tumor, in controlling growth, but only 1/20 1/100 entered draining lymph nodes faster than and caused a accumulation host cells. Both an abrupt termination cell entry into spleen after elimination, this occurred earlier Tc2. Host responses ineffective absence adoptive transfer essential transfer. Perforin expression donor plays no role adoptively transferred control neither IL-4 nor IL5 is needed function. lacking IFN-gamma, however, growth less well, whereas effectors IFN-gamma are unaffected. IFN-gamma-deficient attract fewer node, perforin-deficient donors unimpaired. conclude recruitment crucial element immunotherapy. The differences between EG7 previous melanoma model discussed.