Bone in celiac disease

摘要: Chronic inflammation and malabsorption in celiac disease (CD) can cause bone metabolism alterations mineral loss children adults. Bone status before after gluten-free diet, epidemiology of fractures, possible treatment options for CD-related osteoporosis are presented. Controversial aspects this complication CD discussed. The relationship between derangements was recognized almost 50 years ago, but many questions still open. We now aware that is a relatively frequent atypical presentation CD, especially adults, undiagnosed be the related fractures. inflammatory intestinal diseases, including affect because both systemic local regulatory factors. pathogenetic processes controversial, two main mechanisms seem to involved: presence chronic inflammation. This review analyzes published data on involvement children, adolescents, adults either or diet. Special attention paid fractures patients, considering major an important problem management like CD. usefulness screening osteoporotic patients systematically open question, some rules given. Finally, current Recommendations future clinical research proposed.