Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.

摘要: The transcription factor E2F is a target of the retinoblastoma tumor suppressor protein (pRB) and may mediate pRB regulation S phase entry in mammalian cells. recent identification mutant alleles Drosophila gene (dE2F) has shown that dE2F required for embryogenesis. dE2F-mutant embryos lack co-ordinated program expression which accompanies DNA synthesis declines to levels are barely detectable. We have investigated role at later stages development. expressed several larval tissues cell proliferation eye imaginal disc. Surprisingly, persists post-mitotic cells disc third-instar larvae. loss function these causes novel phenotype, characterized by photoreceptors abnormal rhabdomere morphology. These results show multiple development suggest an important addition its during proliferation.