E2Fs and the Retinoblastoma Protein Family

摘要: The orderly progression through the cell cycle is mediated by sequential activation of several cyclin/cyclin-dependent kinase (cdk) complexes. These kinases phosphorylate a number cellular substrates, among which are product retinoblastoma gene, pRB, and pRB-related proteins p107 p130. Phosphorylation these in late G1 causes their release from heterodimeric transcription factors E2F/DP. This results transcriptional E2F-responsive genes encode that either directly control cell-cycle or function metabolic processes linked to cycle. Thus E2F/DP complexes key signal transducers connecting machinery with sets mediate passage S phases critical regulatory pathway, gates progression, often disrupted during pathogenesis many mammalian tumors. It also plays pivotal role animal development promoting differentiation. We review current state knowledge regarding this pRB/E2F pathway. (Figure 1.1)