Plasma Lipid Profile and Incident Ischemic Stroke The Atherosclerosis Risk in Communities (ARIC) Study

摘要: Background and Purpose— The role of circulating lipids lipoproteins in the pathogenesis ischemic stroke remains uncertain despite 3 decades research. We examined this issue a large population-based cohort. Methods— Between 1987 1989, 14 175 middle-aged men women, free clinical cardiovascular disease, took part first examination Atherosclerosis Risk Communities (ARIC) study Baseline measurements included plasma levels LDL cholesterol, HDL apolipoprotein B, A-1, triglycerides myriad risk factors for disease. cohort was followed disease end points. Results— Over an average follow-up 10 years (142 704 person-years at risk), we documented 305 participants (161 144 women). After multivariable adjustment factors, categorical spline regression analyses entire sample, as well sample alone, revealed weak inco...