DNA polymerases and mutagenesis in human cancers.
作者： Emmanuele Crespan , Alessandra Amoroso , Giovanni Maga
DOI: 10.1007/978-90-481-3471-7_9
关键词:
摘要: DNA polymerases (Pols) act as key players in metabolism. These enzymes are the only biological macromolecules able to duplicate genetic information stored and absolutely required every time this has be copied, during replication or repair, when lost damaged sequences have replaced with “original” “correct” copies. In each repair pathway one more specific Pols required. A feature of mammalian pathways is their redundancy. The failure these can compensated by another one. However, several lesions require a for error free repair. many tumors affected, leading prone some kind alternatives routes, thus accumulation mutations contributing genomic instability, common cancer cell. chapter, we present role Pol genome maintenance highlight connections between malfunctioning progress.
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