Differential expression of DNA repair genes in Hispanic women with breast cancer.

摘要: Previous studies have found a link between low DNA repair capacity (DRC) level and increased risk for breast cancer (BC). A recent study by Matta et al. 2012 showed that women with BC an average reduction of 60% in DRC compared to controls (P < 0.001). Using the same group Hispanic women, we selected subgroup cases (n=35) (n=2) who donated their tumors normal tissue performing molecular order 1) compare expression genes without this disease, 2) assess correlation gene levels, 3) examine whether levels are associated tumor profiling when were stratified according hormone receptor status. measured lymphocytes means host-cell reactivation assay. Gene microarray analysis. Twenty-one be differentially significantly expressed BC. Those candidate CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N (UBC13) XRCC5 (Ku80). Most (n=18 or 82%) overexpressed, ranging from 3.76-fold (RDM1) 1.47-fold (XRCC5). Only 4 (18%) underexpressed, 62% (SAPCD1) 25% (RAD23B). Statistically significant positive correlations FANCB FANCA genes. We discuss clinical translational significance these findings. Our results support usefulness studying as measure risk. This also provides list might dysregulation cancer.