摘要: Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, SOM stable analogue octreotide (OCT) used to treat opioid-resistant pain. animal models, OCT are analgesics released from endings of sensory neurones exerts anti-inflammatory actions. The expression can be modulated by trophic factor glial-cell-line-derived neurotrophic (GDNF). Recent data show that GDNF modulates activity-induced release endogenous both terminals adult neurones. This novel mechanism deserves exploration as potential new therapeutic strategy control two features inflammation: pain leukocyte recruitment.
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