White matter changes in dementia: role of impaired drainage of interstitial fluid.

摘要: White matter abnormalities on magnetic resonance imaging (MRI) are associated with dementia and include white hyperintensities (WMH; also termed leukoaraiosis) visible perivascular spaces (PVS). We review the potential role of impaired drainage interstitial fluid in pathogenesis WMH PVS. Whereas volume extracellular space grey is tightly controlled, accumulates expands acute hydrocephalus, vasogenic edema WMH. Although there no conventional lymphatic vessels brain, very effective for solutes along restricted pathways basement membranes cerebral capillaries arteries young individuals. Lymphatic brain age association apolipoprotein E e4, risk factors Alzheimer's disease amyloid angiopathy (CAA). Deposition proteins walls recognized as protein elimination failure (PEFA), CAA autosomal dominant arteriopathy leukoencephalopathy (CADASIL). Facilitating from aging may play a significant prevention CAA, enhance efficacy immunotherapy disease.