Function of ezrin-radixin-moesin proteins in migration of subventricular zone-derived neuroblasts following traumatic brain injury.
作者： Younghye Moon , Joo Yeon Kim , Woon Ryoung Kim , Hyun Jung Kim , Min Jee Jang
DOI: 10.1002/STEM.1420
关键词:
摘要: Throughout life, newly generated neuroblasts from the subventricular zone migrate toward olfactory bulb through rostral migratory stream. Upon brain injury, these migrating change their route and begin to injured regions, which is one of regenerative responses after damage. This injury-induced migration triggered by stromal cell-derived factor 1 (SDF1) released microglia near damaged site; however, it still unclear how cells transduce SDF1 signals direction. In this study, we found that promotes phosphorylation ezrin-radixin-moesin (ERM) proteins, are key molecules in organizing cell membrane linking extracellular environment intracellular actin cytoskeleton. Blockade ERM activation overexpressing dominant-negative (DN-ERM) efficiently perturbed neuroblasts. Considering DN-ERM-expressing failed maintain proper morphology, appears ERM-dependent regulation shape required for efficient These results suggest an important step directional response SDF1-CXCR4 signaling following injury. STEM CELLS 2013;31:1696–1705
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