MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma.
作者： Yingbin Diao , Hongyu Fu , Qian Wang
DOI: 10.1097/MJT.0000000000000420
关键词:
摘要: MiR-221 is frequently upregulated in papillary thyroid cancer (PTC) tissues and cell lines, this study was designed to validate the association of miR-221 with PTC proliferation, apoptosis, migration. We observed that suppressed TIMP3 expression by binding 3' untranslated region mRNA, increased presence inhibitors; siRNA could reverse effects inhibitors on cells. The results indicated exacerbated downregulating TIMP3. vivo were also confirmed human PTC-bearing mice models which suggest consistent those vitro studies. In summary, aggravate proliferation invasion targeting
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