Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology.
作者： Dong Fan , Zamaneh Kassiri
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摘要: Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its extracellular matrix (ECM)-binding property and broad range inhibitory substrates that includes metalloproteinases (MMPs), a disintegrin (ADAMs), ADAM with thrombospondin motifs (ADAMTSs). In addition metalloproteinase-inhibitory function, TIMP3 can interact proteins in space resulting multifarious functions. mRNA has long 3' untranslated region (UTR) which target for numerous microRNAs. levels are reduced various cardiovascular diseases, studies have shown replenishment ameliorates disease, suggesting therapeutic potential diseases. While significant efforts been made identifying effector targets TIMP3, regulatory mechanism expression this multi-functional TIMP less explored. Here, we provide an overview gene structure, transcriptional post-transcriptional regulators (transcription factors microRNAs), protein structure partners, role pathology application as therapy, while also drawing reference from function other
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