Renal function in gout

摘要: Abstract 1.1. A study was made of renal function in some 300 gouty subjects. Standard clearance technics were employed approximately 160 cases, including asymptomatic hyperuricemic relatives these 2.2. C inulin , PAH and Tm for the most part consonant with values found normal subjects equivalent age, but impairment hemodynamics not infrequent particularly those advanced age or overt disease. 3.3. Determinations urinary urate excretion, whether measured as UV short experiments twenty-four-hour urine collections, gave within range cases. In a significant minority instances, however, excretion unequivocally excess limits variation. 4.4. The filtered load to be increased presumptive tubular reabsorption correspondingly but, so far could determined, disproportionately relation percentage reabsorbed by tubules at loads man. 5.5. results thus indicate essentially discrete functions With advancing years disease, glomerular filtration rate progressively declines apparently deteriorate. Secondary retention then becomes apparent. 6.6. data fail disclose any primary defect function, specifically abnormally enhanced urate. On contrary, imply overproduction gout. This interpretation is supported reference metabolic data. 7.7. question reviewed. available are incompatible view that load, assuming complete filtrability plasma urate, normally wholly very large tubules, excreted derives entirely, greater part, from secretion; analogy potassium pointed out. Indirect direct support this postulation presented. 8.8. It concluded pathogenesis hyperuricemia other manifestations gout cannot ascribed hypothetic defect, great deficient secretion