Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD?

摘要: Kinases are believed to play a crucial role in the expression and activation of inflammatory mediators airway, T-cell function, airway remodeling. Important pro-inflammatory transcription factors such as activating protein-1 nuclear factor kappaB, which activated disease, require kinase switch on genes, while other kinases can regulate mRNA half-life. Selective inhibitors have been developed that reduce gene some characteristics disease animal models. Targeting specific overexpressed or overactive should allow for selective treatment diseases. Interest this area has intensified due success Abelson murine leukemia viral oncogene homolog tyrosine inhibitor, imatinib mesylate, chronic myelogenous leukemia. Encouraging data from models primary cells early phase I II studies diseases suggest p38 mitogen-activated protein inhibitor kappaB kinase-2 may prove be useful novel therapies severe asthma obstructive pulmonary disease.