Ventricular remodeling in heart failure and the effect of β-blockade
作者： James E Udelson
DOI: 10.1016/J.AMJCARD.2004.01.025
关键词:
摘要: Left ventricular (LV) remodeling has an important role in the progression of cardiovascular disease. An understanding process LV led to greater knowledge pathophysiology heart failure. Drug therapies that slow or reverse seem have favorable natural history effects short-term and long-term therapy. Angiotensin-converting enzyme (ACE) inhibitors been associated with a significant reduction mortality, effect beta-blockers on now studied across much spectrum severity patients beta-Blockade seems add independent post-myocardial infarction over above those ACE inhibitors. A combination both drugs shows greatest mortality (ie, most remodeling). Differences their recently shown among beta-blockers. Several studies meta-analysis suggest carvedilol may be more outcome, having remodeling.
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sci-hub.se 参考文章(33)
Capricorn Investigators, Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. The Lancet. ,vol. 357, pp. 1385- 1390 ,(2001) , 10.1016/S0140-6736(00)04560-8
Gary F. Mitchell, Gervasio A. Lamas, Marc A. Pfeffer, Ventricular Remodeling after Myocardial Infarction Advances in Experimental Medicine and Biology. ,vol. 346, pp. 265- 276 ,(1993) , 10.1007/978-1-4615-2946-0_25
M A Konstam, J E Udelson, R D Patten, Ventricular remodeling and its prevention in the treatment of heart failure. Current Opinion in Cardiology. ,vol. 13, pp. 162- 167 ,(1998)
Willem J. Remme, The Carvedilol and ACE-Inhibitor Remodelling Mild Heart Failure EvaluatioN trial (CARMEN)--rationale and design. Cardiovascular Drugs and Therapy. ,vol. 15, pp. 69- 77 ,(2001) , 10.1023/A:1011166919718
John E Sanderson, Skiva K.W Chan, Gabriel Yip, Leata Y.C Yeung, Kam W Chan, Kenneth Raymond, Kam S Woo, Beta-blockade in heart failure Journal of the American College of Cardiology. ,vol. 34, pp. 1522- 1528 ,(1999) , 10.1016/S0735-1097(99)00367-8
Robert N Doughty, Gillian A Whalley, Greg Gamble, Stephen MacMahon, Norman Sharpe, Australia–New Zealand Heart Failure Research Collaborative Group, Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease Journal of the American College of Cardiology. ,vol. 29, pp. 1060- 1066 ,(1997) , 10.1016/S0735-1097(97)00012-0
A. Palazzuoli, F. Bruni, L. Puccetti, M. Pastorelli, P. Angori, A.L. Pasqui, A. Auteri, Effects of carvedilol on left ventricular remodeling and systolic function in elderly patients with heart failure European Journal of Heart Failure. ,vol. 4, pp. 765- 770 ,(2002) , 10.1016/S1388-9842(02)00114-9
K A Krown, M T Page, C Nguyen, D Zechner, V Gutierrez, K L Comstock, C C Glembotski, P J Quintana, R A Sabbadini, Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. Journal of Clinical Investigation. ,vol. 98, pp. 2854- 2865 ,(1996) , 10.1172/JCI119114
Hiroyuki Yaoita, Atsushi Sakabe, Kazuhira Maehara, Yukio Maruyama, Different Effects of Carvedilol, Metoprolol, and Propranolol on Left Ventricular Remodeling After Coronary Stenosis or After Permanent Coronary Occlusion in Rats Circulation. ,vol. 105, pp. 975- 980 ,(2002) , 10.1161/HC0802.104503
Marco Metra, Matilde Nardi, Raffaele Giubbini, Livio Dei Cas, Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy☆ Journal of the American College of Cardiology. ,vol. 24, pp. 1678- 1687 ,(1994) , 10.1016/0735-1097(94)90174-0