Different Effects of Carvedilol, Metoprolol, and Propranolol on Left Ventricular Remodeling After Coronary Stenosis or After Permanent Coronary Occlusion in Rats
作者： Hiroyuki Yaoita , Atsushi Sakabe , Kazuhira Maehara , Yukio Maruyama
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摘要: Background— Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether ischemic LV because of stenosis (CS) or permanent occlusion (CO). Methods and Results— We administered a vehicle, carvedilol, propranolol (2, 10, 30 mg/kg per day, each), metoprolol (6, 30, 90 day), bunazosin (0.2 1 orally for 12 weeks to total 608 rats with CS CO. In these groups the sham (n=40), we assessed function by echocardiography, severity, myocardial blood flow reserve, serum ascorbyl free radical, vitamin C. Both CO increased end-diastolic end-systolic diameters decreased ejection fraction. The 4 agents failed attenuate caused contrast, 3 β-blockers attenuated (P<0.01) tended increase CS. With similar pressure heart rate low...
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