Preoperative hypoxyradiotherapy of colorectal carcinoma.

摘要: The article focuses on the radioprotective effect of acute hypoxia healthy tissues during preoperative accelerated hypoxyradiotherapy colorectal carcinoma performed as locoregional irradiation including common iliac lymph nodes. Analysis early and late side effects complications. Patients Methods: In this prospective study, complications were assessed in 50 patients a function hypoxyradiotherapeutic dose increase. preliminary treatment results radiotherapeutic modification evaluated after median follow-up 48 months using Kaplen-Meier analysis. Between April 1991 February 1997, (36 men 14 women) with treated preoperatively hypofractionated hypoxyradiotherapy. extent disease was classified according to Dukes' criteria (A: four patients, B. 28 C: 18 patients). We used 20-MeV linear accelerator two parallel opposed fields. Hypoxyradiotherapy extending from perineum L4 region. Acute induced by ventilation hypoxic gas mixture containing 7.8–8.0% oxygen. Total doses 24 Gy/8 days, Gy/9 32 Gy/10 days applied five, 20, 25 respectively. Low anterior resection or abdominoperineal amputation rectum day completion reactions Common Toxicity Criteria National Cancer Institute (CTC-NCI). Results: Early postirradiation proctitis documented three radiation-induced cystitis only. Neither nor radiation-associated observed any schedules period 6–105 months. Based Kaplan-Meier analysis (median months), 5-year overall survival rate 61.5% local relapse-free 84.2% can be expected. Treatment failures predominantly systemic. Conclusion: believe it concluded that has normal carcinoma. permits safe administration higher than those tolerated normoxic, noncanceorus tissue, resulting amplification biological radiation tumor tissue contributing an improved outcome combined radiosurgical