Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

摘要: Abstract Background Radiation therapy as an adjunct to surgery for rectal cancer has been shown reduce local recurrence but not improved survival. In a previous study, combined radiation and chemotherapy survival significantly compared with alone, adjuvant radiation, which many regard standard therapy. We designed combination regimen optimize the contribution of chemotherapy, decrease recurrence, improve alone. Methods Two hundred four patients carcinoma that was either deeply invasive or metastatic regional lymph nodes were randomly assigned postoperative alone (4500 5040 cGy) plus fluorouracil, both preceded followed by cycle systemic fluorouracil semustine (methyl-CCNU). Results After median follow-up more than seven years, had reduced 34 percent (P = 0...