Expression and activation of P38 MAP kinase in invasive ductal breast cancers: correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.

摘要: MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and been extensively investigated as putative targets for therapy. This study reports investigation expression P38 MAPK its phosphorylated form (p-P38 MAPK) clinical specimens invasive carcinomas their correlation with estrogen receptor (ER) HER2 expression, well PI3 kinase-AKT pathway proteins. Expression levels p-P38 p-AKT, p-GSK3β, p-S6 kinase, p-MEK1 p-ERK1/2 were quantitatively assessed using multiplex bead immunoassay frozen from 45 ductal cancers. Twenty-nine ER+, 15 HER2+ 10 triple‑negative (TNBCs). was found to be expressed all tumor significantly (P=0.002) overexpressed ER+ tumors. lower TNBCs than other The median also higher tumors while TNBCs. status had no effect on expression. No variation phosphorylation rate observed relation ER, or TNBC status. Significantly (P=0.0048) p-AKT significant difference p-MEK1, p-GSK3β p-S6K any comparisons based ER subtypes. Investigation multiple can used personalized targeted In cancer, overexpression may serve a biomarker evaluation inhibitors.